Catalog Number - 64408-15P

Nova Similars C8™ Octyl is a traditional reversed-phase HPLC stationary phase manufactured on high-purity Type-B spherical silica with a fully endcapped octyl (C8) bonded phase. Designed as a cost-effective alternative to Waters™ Nova-Pak® C8 columns, it offers comparable chromatographic behavior for USP L7 methods while providing the moderate hydrophobic retention and reproducibility expected from a conventional C8 stationary phase. Compared to C18 columns, C8 phases generally provide reduced retention and faster elution of hydrophobic analytes.

64408-15P is a 150 mm x 4.6 mm ID analytical column packed with 4 µm Nova Similars C8 particles. The 150 mm length provides an excellent balance of resolution and analysis time, making it suitable for routine analytical methods, pharmaceutical testing, and quality control applications. The 4 µm particle size provides improved efficiency and somewhat sharper peaks than comparable 5 µm packings while maintaining moderate operating pressure on conventional HPLC systems. Typical operating flow rates are approximately 1.0–2.0 mL/min.

This USP L7 column is ideal for hydrophobic and neutral compounds when less retention is desired than a comparable C18 phase. Common applications include pharmaceutical analysis, long-chain fatty acid separations, method development, and routine analytical testing. This configuration remains one of the most popular Nova Similars C8 columns.

Key Benefits

• Type-B spherical silica stationary phase

• Suitable alternative for USP L7 methods

• Comparable selectivity to Waters™ Nova-Pak® C8 columns

• Balanced resolution and analysis time

• Higher efficiency than comparable 5 µm columns

• Lower retention than C18 columns

• Excellent for hydrophobic and neutral compounds

• One of the most popular Nova Similars C8 columns

Typical Applications

• USP L7 methods

• Reversed-phase HPLC

• Pharmaceutical analysis

• Quality control testing

• Method development

• Long-chain fatty acid analysis

• Routine analytical separations

• Method transfer and validation

Specifications

• Product Type: HPLC Column

• Stationary Phase: Nova Similars C8 Octyl

• USP Classification: L7

• Particle Size: 4 µm

• Particle Type: Type-B Spherical Silica

• Bonded Phase: C8 (Octyl)

• Endcapped: Yes

• Column Dimensions: 4.6 mm ID x 150 mm

• Length: 150 mm

• Recommended Flow Rate: 1.0–2.0 mL/min

• Brand: Cogent

Important Notes

• Designed for reversed-phase chromatography

• 150 mm length balances resolution and analysis time

• Higher efficiency than comparable 5 µm columns

• Moderate operating pressure on conventional HPLC systems

• Provides less retention than comparable C18 stationary phases

• Excellent alternative for many USP L7 methods

• One of the most popular Nova Similars C8 column configurations

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